list+of+ways+that+lifespans+have+been+extended

List of ways that lifespans have been extended methods for making organisms live longer

Overexpression of SIRT3 in HSCs (see Overexpression of SIRT3 in HSCs 2-3-13)

Overexpression of BubR1 to maintain and segregate chromosomes (research performed initially by Mayo researchers) http://www.kurzweilai.net/mayo-clinic-study-unmasks-regulator-of-healthy-life-span @http://news.sciencemag.org/sciencenow/2012/12/revved-up-protein-fights-aging.html BubR1 notes 4-28-13

Transgenic overexpression of catalase in mitochondria (mCAT) in mice increases life span by 20% (5 months) and delays important pathology (Schriner et al. 2005) in The Biology of Human Longevity by Caleb Finch

Natural selection for longer living traits "In a now classic paradigm in the experimental evolution of aging, flies were selected for reproduction at later ages (Rose and Charlesworth, 1980; Rose, 1991). Within 15 generations, this selection regime yielded flies that lived about 20% longer and had more gradual mortality acceleration (Luckinbill et al, 1984; Rose, 1984; Rose et al, 2004)

Diet restriction -Note that diet restriction does not appear to universally increase lifespan/health. Lab mouse strains do experience an increase in lifespan. However, wild type mice experience modest if any gains in lifespan from calorie restriction (The Biology of Human Longevity by Caleb Finch). Also, some mouse strains actually have shortened lifespans with calorie restriction such as the DBA/2 strain. Mice also have decreased fertility with calorie restriction.

simply inject young stem cells into mice http://news.nationalgeographic.com/news/2012/01/120106-aging-mice-stem-cells-old-young-science-health/

parabiotic pairings A young mouse circulatory system is connected to an old mouse circulatory system, and compounds in the young mouse system help the old mouse stay younger. People are trying to figure out what these compounds/factors are. -paper Rejuvenation of aged progenitor cells by exposure to a young systemic environment Irina Conboy paper "F:\kurt\storage\CIM Research Folder\DR\2013\4-29-13\parabiotic pairings.pdf"

block NF-kappaB inflammatory pathway in mice http://www.kurzweilai.net/scientists-discover-how-to-slow-down-aging-in-mice-and-increase-longevity

increase expression of parkin gene for better garbage cleanup http://www.kurzweilai.net/boosting-cellular-garbage-disposal-can-delay-the-aging-process-ucla-biologists-report

Rhodiola rosea herb for stress reduction http://www.kurzweilai.net/herbal-extract-boosts-fruit-fly-lifespan-by-nearly-25-percent

here's some life extension lists from others Twelve Longevity Enhancement Methods Demonstrated in Mice http://www.fightaging.org/archives/2009/08/a-list-of-interesting-longevity-enhancement-methods-in-mice.php

see also gerontogenes and longevity genes http://translate.google.com/translate?hl=en&sl=de&u=http://de.wikipedia.org/wiki/Gerontogen&prev=/search%3Fq%3Dgerontogene%26biw%3D1280%26bih%3D575