Calculating+false+discovery+rate

Here's a paragraph from the wikipedia article on the topic

Large-scale inference
Let be the probability that the null hypothesis is correct, and  be the probability that the alternative is correct. Then times the average p-value of rejected effects divided by the number of rejected effects gives an estimate of the FDR. While we do not know, it is typically close enough to 1 that we can get a reasonable estimate of the FDR by assuming it is 1. This and many related results are discussed in Efron (2010).[|[][|3][|]]