tumor+cDNA+library+papers+10-14-12

[|Mapping the high throughput SEREX technology screening for novel **tumor** antigens.] http://www.ncbi.nlm.nih.gov/pubmed/22221053

[|Identification of a human melanoma antigen recognized by **tumor**-infiltrating lymphocytes associated with in vivo **tumor** rejection]
http://www.pnas.org/content/91/14/6458.short This article was from around 1994 This article [|Progress in human tumour immunology and immunotherapy] cites that one, and is from 2001 same with this one

[|A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening]
from 1997

[|DNA libraries for the construction of phage libraries: statistical and structural requirements and synthetic methods.]

[|Engineering antibodies for cancer therapy.]

=Enhancing cellular cancer vaccines.= http://www.ncbi.nlm.nih.gov/pubmed/20352015

It looks like there are many papers on the SEREX topic. I'm not sure which would be best to choose.

Identification of human tumor antigens by serological analysis of recombinant cDNA expression libraries (SEREX). http://www.ncbi.nlm.nih.gov/pubmed/18432945

Analysis of the B-cell repertoire against antigens expressed by human neoplasms. http://www.ncbi.nlm.nih.gov/pubmed/12445280

Potential target antigens for immunotherapy identified by serological expression cloning (SEREX). http://www.ncbi.nlm.nih.gov/pubmed/17172736

Identification of tumor-associated autoantigens with SEREX. http://www.ncbi.nlm.nih.gov/pubmed/15585919

I think the paper I will choose to read 1st is this one: [|Mapping the high throughput SEREX technology screening for novel **tumor** antigens.] http://www.ncbi.nlm.nih.gov/pubmed/22221053

This journal is only available in print.

So I will read this paper instead [|Progress in human tumour immunology and immunotherapy] file:///home/kurt/Link%20to%202012/10-20-12/Progress%20in%20human%20tumour%0Aimmunology%20and%20immunotherapy.pdf

no immunity found in one study transplanted tumour systems...entail artifactual immunity associated with viral or chemical induction

IL-2 immune manipulation IL-2 expands lymphocytes

'reverse immunology' SEREX

class II restricted antigens

EBV on lymphomas

Wow didn't expect this number Stoler et al. estimated that about 11,000 genomic alterations occur in a cancer cell,

Table 1 Examples of human cancer antigens

Principles of human cancer antigens

quote Study of the immune reactivity of patients with melanoma can identify genes encoding antigens widely expressed on other tumours (such as breast and prostate cancers). These antigens can serve as targets for immune attack.

forgot what exactly delayed hypersensitivity is

TILS = tumour-infiltrating lymphocytes

adoptive therapy

whole tumour cells

avipox virus 'naked' DNA

modified peptides (mutated to bind to anchor to HLA better)

Thus, a successful immune reaction depends on the generation of both CD4+ and CD8+ cells, each of which are stimulated by unique and separate antigens.