Theories+about+reason+some+peptides+on+immunosignature+decrease+11-30-11

One possibility is that the people with the disease who have lower signals for those peptides were not able to produce antibody against these epitopes.

One possibility is that the immune system may down-regulate antibodies to these epitopes because antibodies against these epitopes may be a disadvantage or at least not be optimal.
 * One example of this could be that having an antibody against a decoy protein in the HIV protein would be a disadvantage. I thought I remember Dennis R. Burton talking about such a decoy protein, but I could be wrong. Note that some of the main proteins on the HIV virus are gp41 and gp120