Symposium+Breakout+Session+Proposal+portal+1-12-13

Symposium Breakout Session Proposal portal 1-12-13

The breakout session is taking place 2-23-13. Bo's synthetic biology session will be in the basement of Biodesign My groups Aging and Regenerative Medicine session will be in the Biodesign Auditorium The event will go from 10am-noon.

see e-mail with description of the project here https://mail.google.com/mail/u/0/?ui=2&shva=1#search/breakout/13c1615535500972

some initial documents can be found here C:\kurt\storage\CIM Research Folder\DR\2013\1-12-13\break-out session

submitted breakout proposal "C:\kurt\storage\CIM Research Folder\DR\2013\1-12-13\break-out session\submitted breakout proposal\Break-out proposal_Aging.docx"

Proposal after speakers have been confirmed 2-20-13

My brief introduction of Yonas Geda "Yonas Geda is an Associate Professor of Neurology and Psychiatry and a coinvestigator of the Mayo Clinic Study of Aging. He will be talking about his research on aging, mild cognitive impairment, and dementia."

A map that I sent to Yonas Geda can be found here C:\kurt\storage\CIM Research Folder\DR\2013\2-21-13\biodesign_directions

Checklist for recruitment weekend bring introduction bring poster go to these events: ?

-- 2-24-13 A few points I found interesting from the talks. e-mail here https://mail.google.com/mail/u/0/?ui=2&shva=1#sent/13d0e7167f3865e4

-Julian Chen --talked about many of the historical figures involved with telomerase discoveries: Herman Muller, Elizabeth Blackburn, August Weissmann (around 1881), Hayflick (around 1961), Carol W. Greider (around the 80s) --dyskeratosis congbenita is caused by a mutation in the dyskerin protein. The dyskerin protein is a part of the telomerase holoenzyme complex. Telomerase itself consists of two parts: the protein TERT part, and the RNA part which some people refer to as TERC and some people refer to as TR. These telomerase components interact with other proteins such as DKC1 to form the whole telomerase holoenzyme complex. Right now my understanding of all of the proteins that are a member of the telomerase holoenzyme complex as well as what these different proteins do is very unclear. --Chen is working with a super-active telomerase which can produce longer telomeres faster. I had never heard of a super-active telomerase before. --centenarians and their offspring have longer telomeres compared to the telomeres of the whole population on average --Here are some thoughts triggered by the talk ---There are other things I would like to know more about. For example, if I remember correctly, telomerase can interact with other proteins to turn other genes on and off as well. I would be interested to know what other types of proteins and/or transcription factor proteins telomerase interacts with to do this. Can telomerase act as a transcription factor itself? I don't know. ---There are many factors that can influence the level of expression of telomerase in a cell. For example, I know that estrogen even binds to proteins which then either directly or indirectly influence how proteins bind to the promoter of telomerase and upregulate or downregulate telomerase expression. There are many other compounds besides estrogen that have an influence. I wish I knew much more about this. ---Does telomerase get phosphorylated at various sites to enhance or reduce various functions as many other proteins do?

-Kenro Kusumi --Usually people think that there are a few select animals that can regenerate such as lizards and starfish. However, there are many vertebrates that regenerate, but there are very few mammalian vertebrates that regenerate. --lizards, fish, and alligators regenerate --many different types of stem cells involved in regeneration --fish have heart regenerative ability with cardiomyocytes --adult humans don't get new neurons <- WRONG --mammals can regenerate to a degree during the early postnatal period --myogenic gene networks

-Yonas Geda --primate caloric restriction study at University of Wisconsin (calorie restricted monkeys look younger but angrier haha) --thought triggered by talk: does a certain ethnic group predominantly have the ApoE4 allele associated with alzheimers?

-Jason Scott Robert --euthanasia legal in Oregon, Washington, and Montanna --complications with longer living people: health insurance issues, change in family dynamics, people become too risk averse --primo posthuman: a diagram of a transhuman with various features made by a hypothetical future company with the slogan "evolving at the speed of technology" ---@http://www.natasha.cc/primo3m+diagram.htm ---amusing quote from Susan Ertz: “... millions long for immortality who don't know what to do with themselves on a rainy Sunday afternoon.”