paper+from+sykes+10-13-12

e-mail https://mail.google.com/mail/u/0/?shva=1#advanced-search/from=Kathryn.Sykes%40asu.edu&subset=all&attach=true&within=1d/13a2785f031815c9

paper location /home/kurt/Link to 2012/10-13-12/labinvest2011110a.pdf

High-throughput detection of fusion genes in cancer using the Sequenom MassARRAY platform

recurrent fusion genes/mutations not sure what they mean by non-modal clone don't know what FFPE is FFPE is formalin-fixed, paraffin-embedded

sensitivity vs specificity vs accuracy

These observations lend further support to the suggestion that the majority of expressed fusion genes in usual types of breast cancer are private.

approach described is not suitable for the identification of novel fusion genes and is of limited utility for discovery studies.

they can only identify transcripts that are displayed at the RNA transcript level

no recurrent (fusion) events were identified.

Confirmation of the results with established ‘gold standards,’ such as FISH and RT–PCR, remains necessary.

Sensitivity measures how well a test identifies disease-positive (D+). Specificity measures the probability that a positive test result (T+) correlates to a real D+ person. http://wiki.answers.com/Q/What_is_the_difference_between_sensitivity_and_specificity

Sensitivity (also called recall rate in some fields) measures the proportion of actual positives which are correctly identified as such (e.g. the percentage of sick people who are correctly identified as having the condition)

Specificity measures the proportion of negatives which are correctly identified (e.g. the percentage of healthy people who are correctly identified as not having the condition) http://en.wikipedia.org/wiki/Sensitivity_and_specificity