Age+Associated+Stem+Cell+Autoimmunity

Gemini CTL Project (this link has the original documents explaining the idea for the project)

CTL Assay

__Alternative Methods for Testing this Hypothesis__
 * Just keep doing aged vs young splenocyte vs stem cell experiments in more detail. For example, look at the effect of adaptive vs innate immunity. Also, I could isolate progenitors that express carcinoembryonic self-renewal associated genes (see stem cell comments from John 1-24-13)
 * Vaccinate mice with telomerase and determine if healing rates decrease
 * SCID mouse experiment
 * measure healing rates in mice with SCID
 * ELISA and ELISPOT against stem cell antigens
 * telomerase may be a good antigen to choose
 * Immunosignature of old compared with young
 * Perhaps entropy of immunosignature (distributions of peptide intensities) could be a good thing to measure
 * Tolerance induction (engineered dendritic cells)
 * induce tolerance for stem cells or stem cell markers
 * Replace immune system
 * take away old immune system and replace it with fresh cells

Papers associated with age associated stem cell autoimmunity project

--- paper associated with Gemini Age Associated Stem Cell Autoimmunity project